The Barcelona Institute for Global Health (ISGlobal) is a cutting-edge institute addressing global public health challenges through research, translation into policy and education. ISGlobal has a broad portfolio in communicable and non-communicable diseases including environmental and climate determinants, and applies a multidisciplinary scientific approach ranging from the molecular to the population level. Research is organized in three main areas, Malaria and other Infectious Diseases, Child and Maternal Health, and Urban Health, Climate & Non-Communicable Diseases. ISGlobal is accredited with the Severo Ochoa distinction, a seal of excellence of the Spanish Science Ministry.
The Manhiça Health Research Center (CISM) has among its fundamental activities the development of research on those diseases that most affect the population of Manhiça. On a continuous basis, new research projects in the areas of infectious diseases (malaria, acute respiratory diseases, etc …) have been funded to be carried out and led since Manhiça. In some cases, these projects have a high clinical component that require the researchers who lead them to be clinicians, preferably pediatricians.
Among its fundamental activities, CISM also provides support to the Manhiça District Hospital, the Manhiça Health Center, and health in your study area. These assistance activities are coordinated by the CISM Clinic Department. Essentially, these assistance activities are in the scope of pediatrics, but CISM is also giving specific support to adults.
The project (Stool4TB) involves the validation of new diagnostics for TB, with a focus on children and people living with HIV. The overarching goal of the STool4TB project is to improve TB diagnosis by increasing bacteriological confirmation rates among pediatric and HIV-positive presumptive TB cases.
Stool4TB aims to validate an innovative stool homogenization and DNA isolation method that yields a highly sensitive and specific Mtb qPCR-based diagnostic. STool4TB will evaluate this platform in the high TB and HIV burden settings of Mozambique, eSwatini and Uganda, under the hypothesis that it will narrow the large TB case detection gap by improving TB confirmation rates in children and PLHIV, while proving feasible and acceptable. Preliminary data suggest that this platform adds value to existing sputum based diagnostics and increases rates of bacteriological confirmation. Given the lack of available tools to effectively monitor TB treatment, STool4TB will also evaluate the usefulness of this quantitative stool- based qPCR as a TB treatment monitoring tool for children and PLHIV. This platform has the potential to be adapted to a POC diagnostic and thus easily implemented in resource-constrained basic health care centres. In addition, several epidemiological studies will be nested within the project which will allow the characterization of pediatric TB in one of the most important hotspots of TB and HIV in the world.
This job offer includes the possibility of completing a PhD degree in pediatric TB with ISGlobal and Barcelona University, using original data collected from this project (and potentially other ongoing projects at the TB research unit).
The consortium of partners includes: Fundación Privada Instituto de Salud Global Barcelona (ISGLobal), Spain; Makerere University Uganda, Uganda; Amsterdam Institute for Global Health and Development (AIGHD), The Netherlands; Centro de Investigação em Saúde de Manhiça (CISM), Mozambique; Baylor College of Medicine Childrens Foundation, Swaziland; Baylor College of Medicine, United States; and Research Borstel Center, Germany.
We have identified the need to have an expatriate pediatrician to lead specific clinical research projects and to work in the center’s Tuberculosis Department, with the aim of meeting their general pediatric care needs, facilitating training in pediatric tuberculosis, and take responsibility as an investigator in the field of implementing research tasks in the areas mentioned above.
During the crisis caused by COVID19, standard working conditions will be adapted to sanitary requirements.
